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Topic: High Plasma Phosphatidylcholine DHA Content Associated with Reduced Risk of Dementia
Keywords: DEMENTIA, ALZHEIMER'S DISEASE - DHA, Phosphatidylcholine, Fatty Acids, Diet, Fatty Fish
Reference: "Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study," Schaefer EJ, Bongard V, et al, Arch Neurol, 2006; 63(11)" 1545-50. (Address: Dr. Ernest J. Schaefer, Cardiovascular Research Library, Tufts University School of Medicine, 711 Washington Street, Boston, MA 02111, USA. E-mail: Ernst.schaefer@tufts.edu ).
Summary: In a prospective follow-up study involving 899 subjects (median age: 76 years), high levels of plasma phosphatidylcholine (PD) DHA were found to be associated with a reduced risk of developing dementia. DHA is a fatty acid which is abundant in the brain. Previous research has found that persons with dementia have lower DHA content in the brain. In this study, subjects free of dementia at baseline were followed for an average of 9.1 years. By the end of the follow-up period, 99 new cases of all-cause dementia were found, out of which 71 were Alzheimer's disease. After adjusting for potential confounding factors, subjects in the highest quartile of plasma PC DHA levels were found to have a 0.53 relative risk of developing all-cause dementia and a 0.61 relative risk of developing Alzheimer's disease, compared to subjects in the lower 3 quartiles. Subjects in the highest quartile of plasma PC DHA levels (subset of 488 subjects) were found to consume, on average, 3 servings of fish/week and 0.18 g/d DHA. The results of this study suggest that elderly subjects with high plasma levels of PC DHA have a reduced risk of developing all-cause dementia and Alzheimer's disease, as compared to subjects with lower levels.
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