The Leo J. Bolles Clinic 15611 Bel-Red Rd., Bellevue WA, 98008 (425)881-2224 A PREVENTIVE MEDICINE CENTER

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Nutritional, Biochemical, Vitamin and Mineral deficiencies or imbalances can be a major factor in the prevention, control and cure of disease.
The philosophy of the physicians at the center is to balance the body chemistry, obtain maximum organ function and improve the body's own immune system.
The Bolles Clinic is a management company that provides management services for Independent contractor physicians and other practitioners.
Each practitioner acts of his or her own authority and provides part or all of the services listed.
All medical services are offered only by a licensed medical professional.

Summary# 44626 Keywords: OXIDATIVE STRESS - Curcumin, Curcuma Longa, Turmeric, Curry, Spice, Phytochemicals, Antioxidants Topic: Curcumin Activates Defensive Genes and Protects Neurons Against Oxidative Stress Reference: "Curcumin activates defensive genes and protects neurons against oxidative stress," Scapagnini G, Colombrita C, et al, Antioxidants and Redox Signaling, 2006; 8(3-4): 395-403. (Address: Dr. Giovanni Scapognini, Institute of Neurological Sciences, National Research Council (CNR), V.le Regina Margherita 6, Catania, 95123, Italy. E-mail: g.scapagnini@isn.cnr.it ). Summary: In a study investigating the effects of curcumin – a phytochemical compound and pigment that gives curry its yellow color – which has previously been shown to possess anti-inflammatory and antioxidant properties, administering curcumin to rat type 1 astrocytes was found to upregulate expression of the defense gene, heme oxygenase-1 (HO-1), at both cytoplasmic and nuclear levels. In astrocytes exposed to 5-15 mu M curcumin, a significant expression of two phase II detoxification enzymes was found (quinine reductase and glutathione S-transferase). When cultured hippocampal neurons were incubated with 5-25 mu M curcumin for 6 hours, elevated expressions of HO-1 mRNA and protein were found. When higher doses of curcumin were administered (50-100 mu M), no change in HO-1 expression was found, and a cytotoxic effect was induced. Pre-incubation with curcumin for 18 hours was found to have a cytoprotective effect – enhancing cellular resistance to glucose oxidase-mediated oxidati ve damage. The results of this study add to the growing body of evidence pointing to the potential of curcumin as a potent therapeutic agent in the prevention of various diseases in which oxidative stress plays a role. Click here for products related to this article This article provided by Vitasearch   Email Us! any questions on services on products. Go Back