The Leo J. Bolles Clinic 15611 Bel-Red Rd., Bellevue WA, 98008 (425)881-2224 A PREVENTIVE MEDICINE CENTER

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Nutritional, Biochemical, Vitamin and Mineral deficiencies or imbalances can be a major factor in the prevention, control and cure of disease.
The philosophy of the physicians at the center is to balance the body chemistry, obtain maximum organ function and improve the body's own immune system.
The Bolles Clinic is a management company that provides management services for Independent contractor physicians and other practitioners.
Each practitioner acts of his or her own authority and provides part or all of the services listed.
All medical services are offered only by a licensed medical professional.

Summary# 44627 Keywords: OXIDATIVE DAMAGE, HEART ISCHEMIA, BRAIN ISCHEMIA, STROKE, DIABETIC NEUROPATHY, AGING, ALZHEIMER’S DISEASE - Alpha-lipoic Acid, Lipoate, Vitamin E, Alpha-Tocopherol, Antioxidants, Diet Topic: Alpha-Lipoic Acid and Vitamin E as Therapeutic Agents Reference: "Therapeutic perspectives on the combination of alpha-lipoic acid and vitamin E," Gonzalez-Perez O, Gonzalez-Castaneda RI, Nutrition Research, 2006; 26(1): 1-5. (Address: Neurosurgery and Program in Developmental and Stem Cell Biology, University of California San Francisco, San Francisco, CA 94143, USA). Summary: This review article discusses the therapeutic potential and applications of alpha-lipoic acid (lipoate) (ALA) and vitamin E (VE). Recent findings have shown that ALA plus VE helps to reduce oxidative damage in ischemic and other oxidation-related pathological conditions. Vitamin E is readily found in dietary sources such as wheat germ and various oils such as sunflower, corn and soybean; however, it can be readily destroyed through cooking or commercial processing. Vitamin E has been found to reduce levels of lipid peroxidation and malondialdehyde concentration. ALA is also found in the diet in sources such as wheat germ, beer yeast and red meat. Like vitamin E, ALA has antioxidant properties. In addition, ALA enhances the effects of other antioxidant systems through affecting SOD, coenzyme Q10, and glutathione, in addition to regenerating vitamins C and E. Research is the past 20 years has looked at the potential synergism between ALA and VE, and their application in treating conditions such as diabetic neuropathy, Alzheimer’s disease, rheumatic arthritis, cardiac and cerebral ischemia, and general effects of the aging process. The authors state, "As investigated in the retina, heart and brain ischemia models, the synergistic mechanism of ALA-VE combination is not entirely known, but it is clear that the best in vitro and in vivo antioxidant effects are achieved when both ALA and VE are used simultaneously." Considering the fact that supplementation with both ALA and VE has been found to be safe and well tolerated, in addition to inexpensive, this article concludes by suggesting that while additional research is needed, ALA and VE, through their effects on free radicals, hold great potential as therapeutic agents in the treatment of persons with diabetes, hypertension, cardiac arrhythmias, and heart ischemia.   Email Us! any questions on services on products. Go Back